在接受选择性剖腹产的妇女中治疗产后抑郁症的外科辅助Esketamine:一项随机临床试验
Yu Chen1,2, Yu Guo1,2, Han Wu1,2
1Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China.
在剖腹产产后,外科术期间使用的胺胺可减少产后抑郁症的症状. 这种治疗显示出早期的益处,但可能不适用于所有低抑郁症得分的患者.
科学领域:
- 产科和妇科 产科和妇科
- 麻醉学 麻醉学
- 精神病学是一个精神病学.
背景情况:
- 产后抑郁症 (PPD) 是一种常见的围产期精神健康状况,对母亲和婴儿有不良影响.
- 剖腹产是常见的外科手术,而PPD预防是一个重要的临床关注点.
研究的目的:
- 评估外科手术期间辅助性乙胺在剖腹产后预防PPD的疗效.
- 评估胺对产后早期抑郁症状和术后疼痛的影响.
主要方法:
- 一个单中心,双盲,安慰剂控制的随机临床试验,涉及298名接受选择性剖腹产的妇女.
- 在外科手术期间,参与者接受了静脉注射乙胺或安慰剂.
- 产后抑郁症症状使用爱丁堡产后抑郁量表 (EPDS) 在产后第7天进行评估.
主要成果:
- 素的使用显著降低了产后PD症状在第7天的流行率 (23.0%对35.3%,P=.02).
- 与对照组相比,在乙胺组观察到EPDS得分的显著下降 (P=.008).
- 在以后的时间点中,在PPD查或EPDS得分中没有发现显著差异;然而,在ESKETAMINE组72小时后,手术后运动疼痛较低.
结论:
- 在外科手术期间,静脉注射esketamine可以改善产后早期抑郁症状在接受剖腹产的妇女.
- 对于初始抑郁症得分较高的患者,素的抗抑郁作用可能更为明显.
- 需要进一步的研究来证实长期的疗效和适用于不同患者群体.
更多相关视频
04:51Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
Published on: April 11, 2019
09:07Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
相关概念视频
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Electroconvulsive Therapy
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Depolarizing Blockers: Pharmocokinetics
Antidepressant Drugs: MAOIs and Other Agents
