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在C. elegans中,LPD-3作为抗衰老的大蛋白制动剂和胰岛素-mTOR信号

Taruna Pandey1, Bingying Wang1, Changnan Wang1

  • 1Cardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, CA, USA.

Cell reports
|March 6, 2024
PubMed
概括

一种新型蛋白质LPD-3通过调节胰岛素-mTOR信号传递和脂质代谢来抑制衰老. 随着年龄的增长,它的衰退缩短了寿命,为长寿研究提供了新的目标.

关键词:
CP:新陈代谢过程中的新陈代谢.科普:分子生物学 分子生物学凯诺哈比迪斯的优雅的植物.这就是IIS-mTOR.在INS-7上,我们可以看到INS-7的标志.在 LPD-3 中,LPD-3 是一个非常简单的方法.衰老的衰老 衰老的衰老六甲胺的使用方法功能过高的功能过高功能.线粒体通道的线粒体通道分子损伤是分子损伤.球脂质是指脂质中的一种.

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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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