动脉瘤和心血管事件中的微塑料和纳米塑料
Raffaele Marfella1, Francesco Prattichizzo1, Celestino Sardu1
1From the Departments of Advanced Medical and Surgical Sciences (R.M., C.S., L.S., F.C.S., G.P.), Precision Medicine (N.D., M.L.B.), Engineering (A.F., S.G.), and Mental Health and Public Medicine, Section of Statistics (F.F., I.P.), University of Campania Luigi Vanvitelli, the Department of Forensic, Evaluative, and Necroscopic Medicine, Azienda Sanitaria Locale Napoli 2 Nord (M.M.), the Department of Cardiology, Hospital Cardarelli (M.S., C.M.), the Department of Vascular Surgery, Ospedale del Mare Azienda Sanitaria Locale Napoli 1 (F.S., G.V.), Environmental Technologies, spinoff of University of Campania Luigi Vanvitelli (S.C.), and the Department of Advanced Biomedical Sciences, University Federico II (P.P.), Naples, IRCCS MultiMedica, Milan (F.P., R.L.G., C.F., V.P., A. Ceriello), the Departments of Clinical and Molecular Sciences (G. Fulgenzi, F.O.) and Excellence SBSP-Biomedical Sciences and Public Health (L.G., T.S.), Polytechnic University of Marche, and IRCCS Istituto Nazionale Ricovero e Cura per Anziani (G.M., F.O.), Ancona, the Vascular Physiopathology Unit, IRCCS Neuromed, Pozzilli (C.V.), the Department of Medicine, Surgery, and Dentistry, University of Salerno, Salerno (C.V., A. Carrizzo, G.A., A.S.), the Department of Environmental, Biologic, and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Caserta (G.S., D.M., R.E., S.A., G. Falco, C.L., B.D., P.I.), and the Department of Clinical and Molecular Medicine, Sapienza University of Rome (E.B.), and UniCAMILLUS, International Medical University (G.P.), Rome - all in Italy; Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium (P.P.); Harvard Medical School and the Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston (A.E.C.); and University Hospitals, Case Western Reserve School of Medicine, Cleveland (S.R.).
动脉斑块中的微塑料和纳米塑料 (MNP) 会增加心血管事件的风险. 这项研究在超过一半的患者中发现了MNP,将它们的存在与心脏病发作,中风或死亡的风险增加了4.5倍.
科学领域:
- 心血管科学 心血管科学
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料和纳米塑料 (MNP) 是潜在的心血管疾病风险因素,但人类证据有限.
- 临床前研究表明,MNP可能会影响心血管健康.
研究的目的:
- 为了研究MNP在动脉斑块和人类心血管事件之间的关联.
- 提供MNP在人类心血管疾病中的作用的直接证据.
主要方法:
- 对接受动脉内关节切除术的患者进行前性多中心观察性研究.
- 使用热解气色谱-质谱学,稳定同位素分析和电子显微镜对MNP进行鼻斑块的分析.
- 评估炎症生物标志物和随访主要不良心血管事件.
主要成果:
- 在58.4%的动脉斑块样本中检测到MNP,聚乙烯是最常见的.
- 斑块中存在MNP的患者心肌梗塞,中风或死亡风险显著增加 (HR,4.53;P<0.001).
- 电子显微镜证实了斑块巨细胞内异物颗粒的存在.
结论:
- 鼻动脉斑块中微塑料和纳米塑料的存在与重大心血管不良事件的风险增加有关.
- 这项研究提供了第一个直接的人体证据,将MNP与心血管疾病风险联系起来.
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