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在患有糖尿病视网膜病变的患者中,用扫描源光学连贯性断层扫描血管学测量的白膜尿和视网膜微血管参数之间的关联
Jin Sug Kim1, Eung Suk Kim2, Hyeon Seok Hwang1
1Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, South Korea.
PloS one
|March 6, 2024
概括
在SS-OCTA上增加的毛细血管非 perfusion 区域 (NPA) 与糖尿病视网膜病变患者的albuminuria有关. 这表明SS-OCTA可能有助于早期发现糖尿病病.
科学领域:
- 眼科医生 眼科 眼科
- 腎臟病學 (nephrology) 是一種醫學.
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病视网膜病变 (DR) 是糖尿病的一个常见并发症.
- 糖尿病病 (病) 是另一种严重的并发症.
- 早期发现这两种疾病对于患者管理至关重要.
研究的目的:
- 为了研究尿中白蛋白分泌 (UAE) 和视网膜微血管变化之间的关联.
- 评估扫描源光学连贯性断层扫描血管学 (SS-OCTA) 参数是否与DR患者的白蛋白尿相关.
主要方法:
- 对180名糖尿病患者和50名对照患者进行了回顾性横截面研究.
- 使用SS-OCTA成像来分析视网膜微血管结构.
- 量化了不同视网膜领域的状无血管区,血管密度和毛细血管非 perfusion 区域 (NPA).
主要成果:
- 在75名受试者中发现了白蛋白尿症.
- 毛细管NPA的增加在患有白蛋白尿和DR严重程度高于轻度NPDR的患者中明显大.
- 在6x6mm2和10x10mm2场的NPA是白尿的重要危险因素.
结论:
- 升高的毛细血管NPA与显著的DR患者的白蛋白尿独立相关.
- SS-OCTA显示出作为早期糖尿病病检测的非侵入性工具的前景.
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