在PreventADALL研究中,婴儿时期经常洗油和皮肤屏障
Eva Maria Rehbinder1,2, Sabina Wärnberg Gerdin3,4, Angela Hoyer3,4
1Department of Dermatology, Oslo University Hospital, Oslo, Norway.
婴儿频繁的油浴并不能防止皮肤干燥,并且可能会降低皮肤屏障功能,这表明3个月后皮肤间的水分流失 (TEWL) 较高. 然而,油浴确实减少了在3个月和6个月观察到的干燥皮肤.
科学领域:
- 皮肤病学 皮肤病学
- 儿科 儿科 儿科
- 新生儿护理 新生儿护理
背景情况:
- 以前的研究表明,频繁使用软化浴添加剂并不能预防亚托皮炎.
- 基于矿物质的油浴对婴儿皮肤屏障功能在整个婴儿时期的影响仍然不清楚.
研究的目的:
- 评估基于矿物质的油浴对婴儿皮肤间脱水 (TEWL) 和皮肤干燥的影响.
- 探索是否 filaggrin (FLG) 突变改变了油浴对皮肤屏障功能的影响.
主要方法:
- 一项PreventADALL试验的副研究将2153名婴儿随机分为皮肤干预 (SI) 组 (每周4次油浴) 或没有皮肤干预 (NSI) 组.
- 在3,6个月和12个月测量了皮层间的水分流失 (TEWL);对于一个子集,可获得 filaggrin (FLG) 突变状态.
- 混合效应回归建模评估了干预措施对TEWL和干燥皮肤的影响.
主要成果:
- 在第一年,SI组的平均TEWL比NSI组高 (0.42gm-2h-1),特别是在3个月后.
- 在SI组中,皮肤干燥的频率在3个月 (51%vs. 59%) 和6个月 (53%vs. 63%) 后明显减少.
- 皮肤干预和FLG突变状态之间没有发现显著的相互作用.
结论:
- 从2周大开始频繁的油浴与皮肤屏障功能降低有关,主要是由于3个月时TEWL较高.
- 与对照组相比,接受油浴的婴儿在3个月和6个月时显示皮肤干燥程度较低.
- 这些发现表明,油浴对婴儿皮肤有复杂的影响,影响屏障功能和水合.
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