在国家队列 (COVI-GAPP研究) 中,与SARS-CoV-2感染有关的生理参数的性别特异性差异
Kirsten Grossmann1,2, Martin Risch2,3,4, Andjela Markovic5,6,7
1Private University in the Principality of Liechtenstein (UFL), Triesen, Principality of Liechtenstein.
PloS one
|March 6, 2024
概括
男人和女人对COVID-19感染的生理反应不同,男性在生命体征上表现出更明显的变化. 可穿戴设备可以检测这些性别特异性模式,帮助精准医学.
科学领域:
- 对传染病的生理反应.
- 数字健康和可穿戴技术
- 性作为健康中的生物变量.
背景情况:
- COVID-19 感染会影响各种生理学参数.
- 了解性别差异对于个性化医疗保健至关重要.
- 可穿戴设备提供持续的生理监测.
研究的目的:
- 为了调查COVID-19感染期间生理反应的性别特异性差异.
- 评估用于跨性别检测COVID-19的机器学习算法的性能.
- 探索可穿戴技术在传染病精准医学中的实用性.
主要方法:
- 使用可穿戴设备持续监测呼吸率,心率,心率变化和皮肤温度.
- 每天通过补充应用程序报告症状和混因素.
- 机器学习算法用于追溯COVID-19检测.
- 用多层次建模和t测试分析性别特异性的生理数据.
主要成果:
- 从1163名参与者收集了超过150万小时的生理数据.
- 在症状性COVID-19期间,与女性相比,男性的皮肤温度,呼吸率和心率明显增加.
- 男性的心率变化也比女性减少得更大.
- COVID-19检测算法在两性之间表现相似.
结论:
- 在对COVID-19感染的生理反应中存在明显的性别特异性差异.
- 穿戴式传感器数据可以揭示这些差异性反应.
- 这项研究支持将性别作为生物变量纳入数字健康和传染病精密医学的整合.
相关概念视频
Factors Affecting Body Temperature
4.1K
As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may include:
Factors may include:
4.1K
Physiological Barriers
3.5K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
3.5K
Factors Affecting Pulmonary Ventilation
1.4K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.4K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
91
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
91
Assessing Body Temperature - Temporal Artery
548
Here is a stepwise guide to assessing the body temperature at the temporal artery using a temporal artery thermometer
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.
Step 3: Assess the patient's...
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.
Step 3: Assess the patient's...
548
Assessing Body Temperature - Rectal
4.0K
Rectal temperature measurement is considered the most precise method for assessing core body temperature and typically registers higher than oral temperature. For adults, the rectal thermometer should be inserted 1 to 1.5 inches into the rectum to obtain the most accurate reading.
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
4.0K


