作为急性胰腺炎的预后生物标志物的C-反应蛋白/淋巴细胞比率:一项评估疾病严重程度的横截面研究
Xinqi Chen1, Zhijin Lin, Yani Chen
1Department of Gastroenterology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, People's Republic of China.
International journal of surgery (London, England)
|March 6, 2024
概括
反应性C蛋白/淋巴细胞比率 (CLR) 可以预测中度至严重的急性胰腺炎 (AP). 这种生物标志物显示出非线性关联,较高的CLR表明风险增加,有助于AP的早期检测和预防策略.
科学领域:
- 胃肠病学中的生物标志物
- 炎症疾病标志物 炎症疾病标志物
- 临床诊断 临床诊断 临床诊断
背景情况:
- C-反应蛋白/淋巴细胞比率 (CLR) 被认为是各种疾病的预后生物标志物.
- 在急性胰腺炎 (AP) 中,CLR的预后价值尚未先前确定.
- 了解CLR在AP中的作用对于改善患者的治疗结果至关重要.
研究的目的:
- 调查诊断为AP的患者中CLR和疾病严重程度之间的关联.
- 确定CLR是否可以作为中度至重度AP的预测标记.
- 建立用于AP管理中使用CLR的科学基础.
主要方法:
- 一项涉及476名AP患者的横截面研究,分为轻度 (MAP) 和中度严重/严重 (MSAP/SAP) 组.
- 基线CLR被评估为主要暴露,中度至重度AP的发病率作为主要结局.
- 统计分析包括多变量逻辑回归,受限制的立方线和ROC分析,以评估CLR的预测性能.
主要成果:
- CLR与中度至重度AP的发病率独立相关 (OR,1.04;P < 0.001),表明其预测值.
- 在CLR和AP严重程度之间观察到非线性关系,在约45的值周围观察到和效应.
- 在ROC分析中,CLR具有显著的预测效率 (AUC为87.577%),最佳切断值为30.835.
结论:
- 关于中度至重度AP的发生率,CLR与和效应呈现出非线性关系.
- 在入院后24小时内测量的CLR显示为预测AP严重性的生物标志物.
- 建议进行进一步的研究来验证这些发现,并巩固CLR在AP预测和预防中的作用.
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