在早期发育过程中,在多种不同的皮质区域中共同的模块化架构
Nathaniel J Powell1, Bettina Hein2, Deyue Kong3,4,5
1Optical Imaging and Brain Sciences Medical Discovery Team, Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455.
概括
在感官体验之前,早期的皮质在感官和关联区域中表现出一种共同的模块化组织. 这表明,不同的神经表征是从共同的基础原则中发展出来的.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 动物在复杂的环境中,在皮层区域内发展出多样化的神经表征.
- 这种代表性多样性的起源,无论是区域特定的还是来自共同的初始组织,尚不清楚.
研究的目的:
- 在感官体验之前,研究子发育中的皮质的功能组织.
- 确定早期皮层区域是否具有共同的组织原则.
主要方法:
- 使用双光子和广场成像来记录自发的神经活动.
- 在眼睛/耳朵打开前7-14天,检查了鱼的听觉皮层 (A1),体感皮层 (S1),后壁皮层 (PPC) 和前额皮层 (PFC).
主要成果:
- 所有检查的皮层区域 (A1,S1,PPC,PFC) 的自发活动显示出类似视觉皮层 (V1) 的有组织的模块化结构.
- 这种模块化活动在皮层表面形成了分布式的,毫米尺度的功能网络.
- 在所有区域都观察到高度连贯的自发活动和强大的局部神经元群体相关性.
结论:
- 在传感输入之前,在发育中的皮质中展示了一个共同的,分布的和模块化的功能组织.
- 建议各种皮层表征的开发最初遵循类似的设计原则.
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