童年不良生活事件和骨肌肉线粒体功能
Kate A Duchowny1, David J Marcinek2, Theresa Mau3,4
1Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Science advances
|March 6, 2024
概括
儿童时期的社会压力,就像身体虐待一样,与以后生活中骨肌肉的能量生产降低有关. 这表明线粒体功能障碍可能解释了早期压力如何影响成年人的健康.
科学领域:
- 老年学是指老年学的学科.
- 分子生物学分子生物学
- 心理学 心理学 心理学
背景情况:
- 儿童时期的社会压力是已知的健康不良后果的风险因素.
- 线粒体功能障碍是一种拟议的生物学机制,将早期生活压力与以后的健康联系起来.
- 骨肌肉的线粒体能量对于衰老中的身体功能和代谢健康至关重要.
研究的目的:
- 调查儿童不良事件与老年人骨肌肉线粒体功能之间的关联.
- 检查儿童时期的身体虐待是否会影响腺三酸盐的产生 (ATPmax) 和最大状态3呼吸 (Max OXPHOS).
主要方法:
- 利用了来自肌肉,移动性和衰老研究 (n=879) 的数据.
- 采用线性模型来评估童年不良事件与线粒体能量学之间的关系.
- 测量了最大的腺三酸盐产量 (ATPmax) 和最大的状态3呼吸 (Max OXPHOS),作为线粒体功能的指标.
主要成果:
- 45%的参与者报告至少经历过一次不良童年事件.
- 每个额外的儿童不良事件都与最大腺三酸盐 (ATPmax) 产量显著下降有关 (β = -0.08,95% CI = -0.13, -0.02).
- 儿童不良事件和最大状态3呼吸 (Max OXPHOS) 之间没有发现显著的关联.
结论:
- 儿童期不良事件与老年人骨肌肉ATP产量减少有关.
- 线粒体功能,特别是ATP生产,可以作为一种生物途径,调解早期社会压力的长期健康影响.
- 这些发现凸显了早期生活经验对细胞能量代谢和随后健康的持久影响.
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