混合方法研究多发性骨髓瘤患者金融毒性综合评分响应性的研究
Mark A Fiala1,2, Matthew R Leblanc3, Kathryn W Coccia2
1Division of Oncology, Washington University School of Medicine, St Louis, MO.
JCO oncology practice
|March 6, 2024
概括
金融毒性影响癌症患者. 财务毒性综合评分 (COST) 衡量结果显示,随着时间的推移,财务负担发生了变化,但需要进一步研究来了解这些财务负担的变化.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 心理社会瘤学
背景情况:
- 金融毒性是癌症护理中的重大心理社会负担.
- 金融毒性综合评分 (COST) 越来越多地使用,但缺乏对变化反应能力的数据.
- 了解金融毒性的变化对于患者支持至关重要.
研究的目的:
- 评估金融毒性综合评分 (COST) 仪器对变化的反应能力.
- 探索与金融毒性随时间变化的相关的患者经验.
- 调查COST分数变化与潜在的财务事件之间的关系.
主要方法:
- 一个连续的混合方法研究,涉及72名多发性髓瘤患者.
- 定量阶段:在两个时间点 (8周间隔) 收集的COST分数.
- 定性阶段:半结构面试与12名患者报告显著的得分变化,使用演编码进行分析.
主要成果:
- 平均COST得分的绝对变化为4分;50%的患者经历了得分的恶化.
- 只有58%的受访患者报告了与金融毒性概念模型一致的变化.
- 大多数报告的变化涉及自付医疗费用,非医疗费用或没有客观负担的主观痛苦.
结论:
- 科斯特仪器在患有多发性骨髓瘤的患者中显示了随时间的变化.
- 需要进行进一步的研究,以充分解释COST分数中观察到的变化.
- 调查金融毒性经验的细微差别对于临床实践和患者福祉至关重要.
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