在患有中枢神经系统炎症疾病的儿童中,MOG抗体仅限于脑脊液
Gemma Olivé-Cirera1, Arlette L Bruijstens1, Elianet G Fonseca1
1From the Neuroimmunology Program (G.O.-C., A.L.B., E.G.F., L.-W.C., E.C., E.M.-H., M.G., M.P., R.R.G., Y.B., A.S., J.O.D., T.A.), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona; Pediatric Neurology Department (G.O.-C.), Hospital Parc Taulí de Sabadell, Spain; Department of Neurology (A.L.B.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pediatrics (L.-W.C.), National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Neurology Department (E.M.-H., M.G., M.P., Y.B., A.S., J.O.D.), Institute of Neuroscience, Hospital Clínic, University of Barcelona; Centro de Investigación Biomédica en Red (E.M.-H., M.G., M.P., Y.B., J.O.D.), Enfermedades Raras (CIBERER); Department of Immunology (L.N., R.R.G.), Centre Diagnòstic Biomèdic, Hospital Clínic, Barcelona, Spain; Department of Neurology (J.O.D.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Catalan Institute for Research and Advanced Studies (ICREA) (J.O.D.); and Pediatric Neuroimmunology Unit (T.A.), Neurology Department, Sant Joan de Déu Children's Hospital, ERN-RITA accredited center, University of Barcelona, Spain.
大脑脊髓液 (CSF) 中的髓小细胞糖蛋白抗体 (MOG-abs) 在儿科炎症性中枢神经系统疾病中具有重要作用. 仅限于CSF的MOG-abs的儿童显示出较高的橄克隆带和多发性硬化症的发病率.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 髓寡细胞糖蛋白抗体 (MOG-abs) 涉及到炎症性中枢神经系统 (CNS) 疾病.
- 评估MOG-abs的诊断和预后意义,特别是当它仅限于CSF时,对于儿科患者来说至关重要.
研究的目的:
- 评估在患有中枢神经系统炎症性疾病的儿童脑脊液 (CSF) 中检测到的髓寡基细胞糖蛋白抗体 (MOG-abs) 的临床意义.
主要方法:
- 一项前性多中心队列研究,涉及760名患有获得性脱髓化综合征 (包括ADEM),非ADEM脑炎或非炎症神经系统疾病的儿童 (<18岁).
- 用免疫组织化学和基于活细胞的测试分析了配对的血清和脑脊液样本,以检测MOG-abs.
主要成果:
- 在760名儿童中,109名 (14%) 在血清或脑液中检测出MOG-abs,结果呈阳性. 9名患者 (8%) 仅在CSF中进行MOG-abs.
- 与血清或两样样样本中抗体的儿童相比,患有脑脊液受限制的MOG-abs的儿童年龄较大,更有可能患有脑脊液的寡克隆带 (86%) 和多发性硬化症 (67%) 的诊断.
结论:
- 在血清或脑液中检测到MOG-abs与儿童中枢神经系统炎症相关.
- 在儿科患者中,仅限于脑脊髓的MOG-abs与脑脊髓的较高患病率和多发性硬化症有关,这表明有明显的临床表型.
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