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渔业抗氧化剂4-基胺衍生物:合成,表征和体外评估

Batoul Rostom^1,2, Elizabeth Goya-Jorge^3,4, Liliana Vicet Muro³

¹Laboratoire de Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Conservatoire National des Arts et Métiers (Cnam), HESAM Université, Paris, France.

Canadian journal of physiology and pharmacology

|March 6, 2024

概括

这项研究评估了18种合成4-基胺衍生物的抗氧化活性. 化合物4a表现出优越的自由基清除能力,表现优于BHT和甲酸.

科学领域:

药用化学医学化学
自然产品化学化学
药理学药理学是指药理学的学科.

背景情况:

氨酸在制药和农业食品中至关重要.
4-基胺因其基部分而具有抗氧化潜力.
新型合成衍生品正在不断探索其广泛适用性.

研究的目的:

为了合成和描述12种新型的4-基胺衍生物.
评估18种4-基胺衍生物 (六种商业,12种合成) 的抗氧化活性.
为了研究清理和金属化性质的结构-活动关系.

主要方法:

对于4-基氨酸的两步合成策略.
在体外抗氧化剂测定:DPPH•和ABTS•+激素清除.
在体外铁金属合活性测定.

主要成果:

六种合成氨酸在DPPH•清理中超过BHT.
化合物4a与BHT和甲酸相比,显示出更好的DPPH•清除 (IC50 = 0.05 mmol/L).
九种衍生品表现出显著的ABTS•+清除,与Trolox相比或优于它.
大多数化合物表现出适度的铁化能力 (>20%的几个衍生品).

结论:

在C6位置的替代增强了清理潜力.
提取电子的组可以提高金属化效率.
这项研究提供了对4-基氨酸的抗氧化活性的结构性见解.

关键词:

在ABTS中,ABTS是ABTS.在 DPPH 的情况下,DPPH 是 DPPH.这是一种抗激进药物.基库马林是一种基库马林.在金属化过程中,激进的清洁者彻底的清洁者

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