代谢工程和微生物的发酵,用于生产胡卜素
1Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), KAIST Institute for BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, Daejeon 34141, Republic of Korea.
Current opinion in biotechnology
|March 6, 2024
概括
本审查涵盖微生物胡卜素生产,重点关注代谢工程策略,以提高产量和经济高效的下游加工,用于工业应用.
科学领域:
- 生物技术是生物技术.
- 代谢工程是代谢工程.
- 自然产品 自然产品
背景情况:
- 胡卜素是重要的天然颜料,具有多种工业应用.
- 目前的微生物生产面临着扩大规模和净化方面的挑战.
研究的目的:
- 对高性能胡卜素微生物工厂的先进代谢工程策略进行审查.
- 探索碳酸的成本效益较高的下游加工和净化方法.
主要方法:
- 代谢流量优化优化代谢流量优化
- 酶组装工程 酶组装工程
- 存储容量工程 存储容量工程
- 下游加工和净化技术.
主要成果:
- 代谢工程的进步使实验室规模的胡卜素生产成为可能.
- 工业扩展和经济高效的净化仍然是关键的挑战.
结论:
- 优化的代谢工程和高效的下游加工对于工业化胡卜素生产至关重要.
- 需要进一步的研究来弥合实验室规模的成功与工业可行性之间的差距.
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