在巴西圣保罗州的绵羊群中重新检查甲虫耐药性
Cesar C Bassetto1, Ana Cláudia A Albuquerque2, José Gabriel G Lins3
1Southeast Livestock Unit, Brazilian Agricultural Research Corporation (EMBRAPA), São Carlos, SP, Brazil.
概括
绵羊的胃肠道线虫对常见的虫杀虫剂的耐药性越来越强,导致大量的生产损失. 这项研究揭示了广泛的多重耐药性,需要可持续的控制策略.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 绵羊生产 绵羊生产
- 它具有对虫的抵抗力.
背景情况:
- 胃肠道线虫 (GIN) 像海蒙丘斯形和Trichostrongyluscolubriformis在绵羊养殖中造成重大经济损失.
- 过度依赖甲虫药物导致了对抗性寄生虫种群的选择,损害了治疗疗效.
- 之前的调查表明新出现的耐药性,需要对当前的耐药性状况进行更新评估.
研究的目的:
- 评估目前绵羊群中GIN对甲虫药物的耐药性状态.
- 为了比较各种杀虫剂对流行GIN物种的疗效.
- 评估近几十年来抗甲虫剂耐药性的趋势.
主要方法:
- 在15只绵羊群中进行了便卵数减少试验 (FECRT).
- 动物被分配到用阿尔本达,勒瓦米索尔,伊弗梅克丁,莫内潘特尔,克洛桑特尔或莫克西德克丁治疗的组,以及未经治疗的对照组.
- 使用SHINY工具进行治疗前和后的FECRT分析.
主要成果:
- 海蒙丘斯 (Haemonchus spp.) 的一种. 是发现的最常见的线虫.
- 平均疗效差异很大:阿尔本达 (40%),莱维米索尔 (可变,在2个农场高),伊弗梅克丁 (34%),莫克西德克丁 (21%),克洛桑特尔 (63%) 和莫尼潘特尔 (79%).
- 在所有被调查的群体中,多重抗甲虫剂耐药性普遍存在,莫尼潘特尔仅在五个农场显示≥95%的有效性.
结论:
- 绵羊中广泛存在的多种甲虫抗药性GIN对绵羊生产构成重大威胁.
- 通常使用的杀虫剂的疗效正在下降,突出显示治疗失败.
- 紧急实施可持续的综合性寄生虫管理策略对于在绵羊养殖中有效控制GIN至关重要.
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