合成,表征,分子建模,氏素β-环氧德克斯-纳入复合物的结合能:在β-CD复合后的光物理行为改变
Karuppiah Nagaraj1, Chelladurai Karuppiah2, Mohammad Ahmad Wadaan3
1School of Pharmacy, National Forensic Sciences University, 6M56+XP8, Police Bhavan Rd, Sector 9, Gandhinagar, Gujarat 382007, India.
奎尔素是茶叶中的天然黄类化合物,它与环氧素 (CDs) 形成含有复合体. β-cyclodextrin (β-CD) 增强了氨酸的可溶性,稳定性和生物可用性,结合亲和力因CD类型而异.
科学领域:
- 自然产品化学 自然产品化学
- 超分子化学 超分子化学
- 分析化学 分析化学
背景情况:
- 奎尔赛丁是一种天然存在的黄类化合物,具有潜在的健康益处.
- 循环德克斯特林 (CDs) 是循环寡糖,用于改善客分子的特性.
- 了解氨酸-环氧氨酸相互作用对于制药应用至关重要.
研究的目的:
- 调查奎尔丁与各种环极素的纳入复杂化.
- 描述奎尔丁-CD复合体的结合行为和固态度.
- 评估循环德克斯林复合对奎尔塞丁性质的影响.
主要方法:
- 频谱分析 (UV-Vis,发射,FT-IR,ICD) 是一个非常简单的方法.
- 核磁共振 (NMR) 光谱学 (1H, 13C) 的使用
- 电子喷雾电离质谱仪 (ESI-MS) 是一种电子喷雾电离质谱仪.
- 能源最小化研究研究.
- 阶段溶解性研究阶段溶解性研究.
主要成果:
- 奎尔素与α-,β-,γ-CDs,per-6-ABCD和mono-6-ABCD形成了包括综合体.
- 复杂的形成取决于宿主: 客人 石化学.
- β-CD复合显著提高了氨酸的水溶性,化学稳定性和生物可用性.
- 结合亲和度顺序:每-6-ABCD > 单-6-ABCD > γ-CD > β-CD > α-CD.
- 阶段溶解性研究证实了1:1宿主-客人复合体.
结论:
- 循环德克斯特林复合是一种有效的策略,可以增强奎尔塞丁的药物特性.
- 这项研究提供了详细的洞察力,了解奎尔塞丁与不同环氧德克斯特林之间的结合相互作用.
- β-CD 是一个有前途的宿主,可以改善氨酸的输送和疗效.
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