在Robo3cKO小鼠的初级体感皮层中,双边胡须的表现反映在初级运动皮层中
Vassiliy Tsytsarev1, Céline Plachez1, Shuxin Zhao1
1Department of Neurobiology, University of Maryland School of Medicine, 20 Penn St, HSF-2, Baltimore, MD 21201, USA.
Neuroscience
|March 6, 2024
概括
机器人3基因缺陷导致主要运动皮质 (M1) 中的双边胡须图. 这是因为三次明othalamic投射不能穿过中线,影响从主要体感皮层下游的感觉处理.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 感官系统 感官系统
背景情况:
- 机器人3基因突变破坏了感觉路径的中线交叉.
- 这导致了体感性丘脑和主要体感性皮层 (S1) 中的双边胡须图.
研究的目的:
- 调查双边胡须代表是否延伸到下游的汽车领域.
- 为了确定S1投射到主要运动皮质 (M1) 是否受到Robo3诱导的中线交叉缺陷的影响.
主要方法:
- 级病毒轴突追踪被用来标记S1投影.
- 进行电压敏感染色成像 (VSDi) 来评估大脑激活模式.
- 单个胡须刺激应用于ipsilateral和contralateral侧面.
主要成果:
- 从S1到M1的皮质皮质投射在对照和Robo3cKO小鼠中是相似的.
- 与对照小鼠不同的是,Robo3cKO小鼠在胡须刺激时表现出双边激活在皮层和M1中,与对照小鼠不同.
结论:
- 在三角体内突出的中线交叉缺陷导致M1.1的双边胡须表示.
- 包括M1在内的S1下游的感觉处理受到发育中线交叉异常的影响.
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