暴露于各种工作环境和时间的耐药真菌
Victor Carp Kofoed1, Christopher Campion1, Pil Uthaug Rasmussen1
1National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen Ø, Denmark.
The Science of the total environment
|March 6, 2024
概括
丹麦工人接触到空气中的抗真菌耐药菌,特别是在生物燃料工厂. 这项研究确定了耐药的阿斯伯吉勒斯菌种,突出了职业暴露风险.
科学领域:
- 环境微生物学环境微生物学
- 职业健康 职业健康 职业健康 职业健康
- 医学真菌学 医学真菌学
背景情况:
- 抗真菌耐药性是一个日益增长的全球健康威胁.
- 关于职业接触抗真菌耐药性真菌的数据有限.
- 了解暴露途径对于公共卫生至关重要.
研究的目的:
- 评估丹麦工人的职业暴露在对第一线抗真菌药物耐药的空气传播真菌.
- 在各种工作环境中识别特定的真菌物种和抵抗机制.
- 确定工作环境对抗真菌耐药性暴露的贡献.
主要方法:
- 20年来,对来自丹麦工作场所 (农业,动物处理,废物管理,医疗保健) 的669个个人暴露样本进行了回顾性分析.
- 使用MALDI-TOF MS进行真菌鉴定,并通过calmodulin和β-tubulin基因测序进行确认.
- 对495种真菌分离物进行抗真菌敏感性测试,对伊特拉科纳,沃里科纳,波萨科纳和安福特里辛B进行检测.
主要成果:
- 在不同的工作环境中,真菌暴露和物种组成的显著变化.
- 在30个分离物体中检测到抗药性,包括Aspergillus fumigatus,A. niger复合物,A. versicolor和A. lentulus.
- 在A. niger复合体内识别神秘物种,检测耐药A. fumigatus中的TR34/L98H突变.
结论:
- 工作环境,特别是生物燃料工厂,对职业接触抗真菌耐药性真菌有很大影响.
- 种类组成影响了职业环境中抗真菌耐药性的流行.
- 需要进一步的研究,以减轻暴露风险,并在工作场所管理抗真菌耐药性.
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