在感染控制中,用于持续释放抗生素的telodendrimer功能化水凝平台
Xiguang Yang1, Dandan Guo1, Xiaotian Ji1
1Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, NY 13210, United States.
Acta biomaterialia
|March 6, 2024
概括
一个新的telodendrimer (TD) 水凝平台有效地加载抗生素以持续释放,改善伤口感染治疗. 这种受控释放降低了细胞毒性,并在临床前模型中增强了抗菌疗效.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 伤口感染显著延迟愈合,造成医疗保健负担很大.
- 当地的抗生素输送是慢性伤口管理的一个有希望的策略.
- 现有的方法可能会遭受突发释放和相关的细胞毒性.
研究的目的:
- 开发和表征一个多功能型的telodendrimer (TD) 水凝平台,用于有效的抗生素加载和持续释放.
- 优化抗生素有效载荷含量和释放配置文件,以有效控制伤口中的感染.
- 评估抗生素装载的TD水凝的抗菌作用力,细胞毒性和体内疗效.
主要方法:
- 在一个生物相容的水凝中结合的远端膜体 (TD) 平台的开发.
- 使用充电和疏水相互作用来加载充电的抗生素 (例如,聚氨酸B, gentamycin, daptomycin).
- 优化控制药物释放的TD密度和价值.
- 在体外评估药物载荷能力,释放动力学,抗菌作用力和细胞毒性.
- 在肌肤和软组织感染的小鼠模型中的体内评估.
主要成果:
- 达到高药物载荷能力 (最高可达20%的药物与树脂干重比).
- 通过调整TD密度来证明可调和和持续释放的配置.
- 带有抗生素的TD水凝显示出与免费抗生素相比,抗菌疗效与降低细胞毒性相比相当.
- 在小鼠感染模型中,皮下注射含有PMB的TD水凝有效清除了细菌负担.
结论:
- 可设计的TD水凝提供了一个多功能平台,用于局部治疗伤口感染.
- TD水凝的可调性特性允许优化抗生素的输送和增强治疗结果.
- 这个平台具有很大的潜力,可以通过有效控制感染来促进伤口愈合.
相关概念视频
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
137
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
137
01:23Modified-Release Drug Delivery Systems: Classification
315
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
315
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
172
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
172
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
177
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
177
01:26Oral Drug Delivery Systems: Continuous-Release Systems
308
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
308
01:11Oral Drug Delivery Systems: Delayed-Release Systems
222
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
222