葡萄糖敏感胰岛素微针贴片用于长效的输送和释放可视化
Ye He1, Nanxi Chen1, Mingming Zang1
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
概括
这项研究介绍了创新的三重结构微针 (MNs) 用于智能胰岛素输送. 这些MN提供了改善的药物加载,完全释放,以及糖尿病管理的视觉指标.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 内分泌学 在内分泌学.
背景情况:
- 传统的聚合物微针 (MNs) 面临着有限的药物加载和不完全的药物释放的挑战.
- 智能控制释放MN需要明确的药物释放完成指标来指导患者的剂量.
- 不确定的药物释放时间需要可靠的方法来监测治疗终点.
研究的目的:
- 开发具有增强药物加载和控制释放能力的新型微针 (MNs).
- 创建一个视觉指标,用于完成MN的药物释放.
- 为了改善糖尿病模型中的血糖控制,使用一种对葡萄糖敏感的MN系统.
主要方法:
- 一个三重结构的微针 (MN) 的构造,具有对葡萄糖反应的外,胰岛素粉末和彩色的推进内核.
- 使用透机制来控制药物释放.
- 在糖尿病小鼠体内测试以评估低血糖效应和持续时间.
主要成果:
- 设计的MNs表现出优异的胰岛素载荷和更完整的药物释放.
- 在糖尿病小鼠中观察到正常血糖时间的显著延长 (长达24小时),0.3厘米2的补丁.
- 内核的色为药物释放过程提供了清晰的视觉指示.
结论:
- 三重结构的MNs为智能,可控和可视化药物递送提供了一个有前途的平台.
- 这种设计克服了传统MN的局限性,改善了药物加载和释放的完整性.
- 开发的系统可促进不间断的闭环治疗,并可适应其他智能MN药物递送系统.
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