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针对CXCL12/CXCR4通路,以减少辐射治疗的副作用

Naz Chaudary¹, Richard P Hill², Michael Milosevic³

¹Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

|March 6, 2024

概括

准CXCL12/CXCR4通路显示有望减少放射治疗的副作用. 抑制这种途径可以减轻正常组织损伤,改善患者在放射治疗中的结果.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
免疫学免疫学免疫学

背景情况:

放射治疗 (RT) 提供了改善的结果,但可能会导致严重的副作用,限制治疗的疗效.
正常组织的辐射耐受性是一个主要的挑战,特别是在重新治疗场景.
以前的放射性防护药物由于疗效,瘤保护或毒性问题而表现出有限的临床成功.

研究的目的:

审查针对CXCL12/CXCR4通路作为减轻辐射诱导正常组织损伤的策略的证据.
评估CXCL12/CXCR4抑制的潜力,以克服以前辐射保护方法的局限性.

主要方法:

对研究CXCL12/CXCR4信号传导在RT诱导的正常组织损伤中的作用的临床前研究的综述.
对抑制这种途径对各种正常组织 (皮肤,肺,肠道,大脑) 的影响的数据分析.

主要成果:

RT上调CXCL12信号,吸引表达CXCR4的炎症细胞,使急性损伤和晚期纤维化恶化.
在RT期间或之后抑制CXCL12/CXCR4信号传递有效地减少或防止RT在临床前模型中的副作用.
这种方法证明了治疗潜力,没有明显的并发性瘤保护问题.

结论:

准CXCL12/CXCR4通路是减少放射治疗副作用的有希望的策略.
需要进一步的临床研究和药物开发来将这些发现转化为患者护理.
这种方法提供了一个潜在的解决方案,以克服辐射保护中以前的翻译挑战.

关键词:

在CXCL12中,CXCL12是最重要的.在CXCR4中,CXCR4是最常见的.无线电保护是一种无线电保护.辐射疗法辐射疗法有毒性有毒性

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