持续的神经肌肉阻塞用于支气管肺形
Emily D Johnson1, Kristopher Keppel2, LeAnn McNamara3
1Department of Nursing, Johns Hopkins Hospital, Baltimore, Maryland.
American journal of perinatology
|March 6, 2024
概括
对于患有严重支气管肺功能障碍 (BPD) 的早产婴儿,超过25天的长期持续神经肌肉阻塞 (CNMB) 与没有幸存者有关. 这种治疗没有改善线性生长,并显示出高死亡率.
科学领域:
- 新生儿医学 新生儿医学
- 儿科重症监护 儿科重症监护
- 呼吸系统医学 呼吸系统医学
背景情况:
- 支气管肺功能障碍症 (BPD) 是早产婴儿的常见并发症.
- 持续神经肌肉阻塞 (CNMB) 在严重的BPD病例中使用,但其对结果的影响尚不清楚.
研究的目的:
- 调查CNMB的持续时间和严重BPD婴儿的死亡率之间的关联.
- 评估CNMB对严重BPD婴儿线性生长的影响.
主要方法:
- 对2016年至2022年期间入院的5岁以下儿童进行了回顾性医疗记录审查.
- 该研究包括患有BPD的婴儿,这些婴儿接受了至少14天的CNMB疗程中的一个或多个.
主要成果:
- 12名婴儿接受了中位数为14-173天的CNMB治疗. 大多数是早产 (<28周怀孕) 并且出生时体重低 (<1000克).
- 在12名婴儿中,只有2名婴儿存活到出院. 两名幸存者都接受了CNMB不到25天.
- 在大多数患者中,线性增长Z-score下降,只有一个婴儿实现了最终长度Z-score大于-2.2的结果.
结论:
- 在接受25天或更长时间CNMB的严重BPD婴儿中没有观察到幸存者.
- 长时间的CNMB似乎没有改善这个队列的线性增长.
- 这些发现不支持使用扩展CNMB来预防严重BPD的死亡率.
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