同时服用药物的对氧化环酸盐水合物在人造肠道果汁中的影响
Yuri Mizuno1, Fumihiko Ogata1, Yugo Uematsu1,2
1Faculty of Pharmacy, Kindai University.
Chemical & pharmaceutical bulletin
|March 6, 2024
概括
环酸盐水合物 (SZC) 通过常见的心脏药物有效地控制高胆血症. 和这些药物不会干扰肠道中的SZC,确保安全的同时使用.
科学领域:
- 药理学和药物相互作用
- 胃肠道药物吸收 药物吸收
- 脏病学和电解质平衡的研究
背景情况:
- 高血症是一种严重的疾病,通常需要使用结合剂进行治疗.
- 环酸 (SZC) 是一种用于高血症的结合剂.
- 患有高血症的患者经常同时服用药物,包括抗剂和β-阻断剂,需要评估潜在的药物相互作用.
研究的目的:
- 调查SZC和常见的心血管药物之间的潜在药物相互作用.
- 为了评估阿姆洛迪平,尼费迪平,卡维迪醇和比索普罗醇对SZC结合能力的影响.
- 为了评估离子和这些并发药物对SZC在人工肠道环境中的施用的影响.
主要方法:
- 评估SZC,聚二硫酸盐 (CPS) 和聚二硫酸盐 (SPS) 的离子吸附能力.
- 确定每个结合剂的吸附平衡时间.
- 在SZC,SPS和CPS的存在下,量化了阿姆洛迪平,尼费迪平,卡维迪洛和比索普罗洛的残留百分比.
- 使用元素分析分析SZC相互作用后的表面组成.
- 评估了离子和并发药物对SZC在人造肠汁中给药的影响.
主要成果:
- 与CPS和SPS相比,SZC显示出最高的离子吸附能力 (90.8 mg/g).
- 在SZC的1小时内达到吸附平衡,而CPS和SPS的1分钟.
- 与SPS (0.38-38.4%) 和CPS (0.57-29.0%) 相比,amlodipine,nifedipine,carvedilol和bisoprolol的残留百分比在SZC (79.0-91.9%) 显著更高.
- 在SZC表面检测到来自药物的碳,和氧成分.
- 离子和并发药物并没有干扰SZC在人造肠汁中的使用.
结论:
- 在阿姆洛迪平和卡维迪洛尔等常见心血管药物的存在下,SZC有效地管理高卡利米亚.
- 在人造肠道环境中,SZC与抗体和β阻塞剂的药物相互作用最小.
- 这些发现支持SZC与这些并发药物的安全同时使用,提供了有价值的临床见解.
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