[在人类免疫缺陷病毒阴性患者的同一个淋巴结中与卡波西肉瘤并发的大B细胞淋巴瘤]
Shiori Nakashima1, Shin Ohara1, Yui Imai1
1Department of Hematology, Eiju General Hospital.
概括
这项研究报告了一例罕见的同时扩散的大B细胞淋巴瘤 (DLBCL) 和人类疹病毒8-阳性卡波西的罕见病例.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 血液学 血液学 血液学
背景情况:
- 卡波西肉瘤 (KS) 是一种定义艾滋病的疾病,但可以发生在HIV阴性个体中.
- 扩散性大B细胞淋巴瘤 (DLBCL) 是一种侵略性的非霍奇金淋巴瘤.
- 在淋巴结中同时出现KS和淋巴瘤是非常罕见的.
研究的目的:
- 报告在HIV阴性患者中同时发生的DLBCL和HHV-8阳性KS的独特病例.
- 突出这种罕见的双重恶性瘤的诊断和治疗挑战.
- 贡献到关于同时发生KS和淋巴瘤的有限文献.
主要方法:
- 系统性淋巴腺病的临床表现.
- 通过淋巴瘤和HHV-8的免疫组织化学证实了诊断.
- 用组合化疗治疗 (利图西马布,皮拉鲁比辛,环胺,温克里斯,普雷迪尼索隆).
主要成果:
- 这位患者出现了被诊断为DLBCL的淋巴腺病变和HHV-8阳性的KS.
- 淋巴瘤细胞被证实是HHV-8负的.
- 在六轮化疗后,完全缓解.
结论:
- 这是第一个报告的同时DLBCL和HHV-8阳性的KS病例.
- 这一案例强调了对同时存在的恶性瘤进行彻底的组织病理学评估的重要性.
- 通过标准化疗成功治疗这种罕见的表现,提供了一种潜在的治疗方法.
相关概念视频
Pulmonary Tuberculosis I
242
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
242
Immunodeficiency Diseases
937
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
937
Sexually Transmitted Infections
306
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
306
Retrovirus Life Cycles
46.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.0K
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K


