![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
[用伊诺图祖马布 (inotuzumab) 的顺序治疗,然后用CAR T细胞治疗费城染色体阴性急性淋巴细胞白血病]
Yo Mizutani1, Shinsuke Kusakabe1, Kentaro Fukushima1
1Department of Hematology and Oncology, Osaka University Graduate School of Medicine.
概括
这项研究表明,将抗体合物与CAR-T细胞疗法结合起来,可以有效地治疗复发的B细胞急性淋巴细胞白血病 (ALL). 这种连续的双向方法可以在年轻成人患者中以最小的器官损伤实现深度缓解.
科学领域:
- 血液学 血液学 血液学
- 免疫治疗是一种免疫疗法.
- 在瘤学瘤学.
背景情况:
- 一名25岁的女性,有B细胞急性淋巴细胞白血病 (ALL) 的病史,呈现出白血细胞病.
- 该患者此前曾参与日本儿科白血病/淋巴瘤研究小组 (JPLSG) 的临床试验.
研究的目的:
- 评估一种连续的双向疗法,结合抗体结合物和化学抗原受体T细胞 (CAR-T) 治疗复发ALL.
- 评估该策略在实现深度缓解和维护器官功能的有效性和安全性.
主要方法:
- 通过多色流细胞计和PCR-MRD确认了ALL复发的诊断.
- 该患者接受了两次伊诺图祖马布臭胺素治疗周期作为桥梁治疗.
- 随后进行了化学抗原受体T细胞 (CAR-T,Tisagenlecleucel [Tisa-cel]) 治疗.
主要成果:
- 桥梁疗法实现了血液学完全缓解,尽管具有阳性PCR-MRD (1.0×10−4).
- 卡特-T疗法导致MRD阴性和完全缓解.
- 患者仍然处于完全缓解状态,并持续进行MRD监测.
结论:
- 结合抗体结合体和CAR-T细胞的序列双向疗法是复发ALL的有效治疗方法.
- 这种策略在更深度的缓解中提供了改善的瘤控制,并通过减少细胞毒剂的使用来最大限度地减少器官损伤.
- 这种方法是青少年和年轻成年ALL患者的合理和有效的治疗选择.
相关概念视频
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:27Tumor Immunotherapy
524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K