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在接受乙型肝炎免疫球蛋白的肝移植患者中,乙型肝炎病毒的重新激活

Anar Ganbold¹, Sumiya Bayarsaikhan¹, Munkhtsetseg Chimedtseren¹

¹Gastroenterology Center, The First Central Hospital of Mongolia, Ulaanbaatar, Mongolia.

Clinical transplantation and research

|March 6, 2024

概括

乙型肝炎免疫球蛋白 (HBIg) 没有阻止肝移植后的乙型肝炎病毒 (HDV) 活性化. 高效的核类同类 (NA) 有效地抑制高强度病毒,大多数反激活是轻微的和自我限制.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
移植手术移植手术

背景情况:

在肝移植 (LT) 后,B型肝炎免疫球蛋白 (HBIg) 对于预防D型肝炎病毒 (HDV) 再激活的实用性有争议.
这项研究评估了外科手术期间HBIg对LT接受者的HDV再激活的保护作用.

研究的目的:

为了比较接受外科手术期间HBIg治疗的LT患者与没有接受外科手术期间HBIg治疗的LT患者的HDV再激活率.
评估核类同类 (NA) 在抑制LT后的HDV中的有效性.

主要方法:

这是一项单一中心研究,对57名患有乙型肝炎病毒 (HBV) 和HBV/HDV感染的LT接受者进行了单一中心研究.
评估了HBsAg,抗HDV抗体,HBVDNA和HDVRNA水平. 这些都是值得考虑的.
通过面试和肝功能测试评估NA治疗方案的遵守和移植前的HBV/HDV状态.

主要成果:

在HBIg和非HBIg组之间,没有观察到HDV RNA,HBV DNA,HBsAg或抗HDV阳性的显著差异.
所有报告的HDV再激活发生在不遵守NA治疗方案的患者中.
大多数最初仅感染HBV的患者在移植前被发现是抗HDV阳性.

结论:

术后的HBIg没有证明对LT后的HDV再激活有保护作用.
高效的NA在维持HDV抑制方面是有效的.
复发性肝炎D病例通常是轻微的和自我限制的.

关键词:

乙型肝炎的免疫球蛋白是B型肝炎的免疫球蛋白.乙型肝炎病毒的感染.肝炎D病毒的重新激活.肝脏移植肝脏移植

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