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Updated: May 26, 2026

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cirCodAn:基于GHMM的工具,用于准确预测circRNA中的编码区域

Denilson Fagundes Barbosa¹, Liliane Santana Oliveira², Pedro Gabriel Nachtigall³

¹Programa de Pós-Graduação Associado em Bioinformática (UFPR/UTFPR), Departamento Acadêmico de Computação (DACOM), Universidade Tecnológica Federal do Paraná (UTFPR), Cornélio Procópio, Paraná, Brazil; Instituto Federal de Educação, Ciência e Tecnologia de Santa Catarina (IFSC), Canoinhas, Santa Catarina, Brazil.

Advances in protein chemistry and structural biology

|March 6, 2024

概括

一个名为cirCodAn的新工具精确地检测圆形RNA (circRNAs) 中的编码区域,进步研究它们在疾病和生物过程中的作用. 这个工具有助于识别潜在的circRNA编码的蛋白质.

科学领域:

分子生物学分子生物学
生物信息学是一种生物信息学.
基因组学就是基因组学.

背景情况:

循环RNAs (circRNAs) 越来越多地被认为是它们在生物过程和疾病中的作用.
具有翻译潜力的circRNA的特征对于理解它们的功能至关重要.
现有的用于开放式读取检测的工具对于循环序列是无效的.

研究的目的:

介绍cirCodAn,这是一个用于预测circRNAs编码区域的新型计算工具.
解决当前工具在检测循环序列中的开放阅读框架方面的局限性.

主要方法:

开发cirCod一个用于circRNA开放阅读框架预测的工具.
使用circRNA数据集与实验翻译证据评估cirCodAn的性能.

主要成果:

与现有的工具相比,cirCodAn在检测circRNAs内的编码区域方面表现出卓越的准确性.
该工具成功地在circRNA中识别了具有强有力的翻译证据的潜在编码区域.

结论:

cirCodAn是识别circRNAs编码潜力的宝贵工具.
这种工具将促进未来研究circRNA及其编码的生物学作用.
cirCodAn是免费提供用于科学研究.

关键词:

循环RNA 是一个循环RNA.编码区域预测的预测一般化隐藏的马尔科夫模型概率模型是一种概率模型.文字转录学 (Transcriptomics) 是一个学科.

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Cis-regulatory Sequences

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...

Cis-regulatory Sequences

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...