身体活动和身体质量与童年追赶肺功能增长有关:基于人口的加速队列研究
Sarah Koch1,2,3, Gabriela Prado Peralta4,2,3,5, Anne-Elie Carsin4,2,3,6
1Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain sarah.koch@isglobal.org.
Thorax
|March 6, 2024
概括
这项研究确定了儿童的四种肺功能轨迹,包括追赶增长模式. 身体活动和早期体重指数预测FEV1的追赶肺功能增长,但不是FVC.
科学领域:
- 儿科肺病学 儿科肺病学
- 增长和发展 增长和发展
- 流行病学 流行病学
背景情况:
- 儿童的肺功能轨迹尚未得到充分了解.
- 识别肺功能增长的预测因素对于早期干预至关重要.
研究的目的:
- 在基于人口的出生队列中确定不同的肺功能轨迹.
- 确定与这些肺功能轨迹相关的预测因素,包括追赶增长.
主要方法:
- 基于组的轨迹建模被用于分析1秒内强制呼气体积 (zFEV1) 和强制生命能力 (zFVC) 的z-score.
- 从1151名儿童的数据被评估在多个时间点,从4岁到18岁.
- 多项逻辑回归确定了产前/产后因素和肺功能轨迹之间的关联.
主要成果:
- 确定了四个轨迹:低,正常,高 (平行运行) 和追赶轨迹 (发生在4-10岁之间).
- 在4岁时,较少的过敏性疾病和较高的体重指数z-score (zBMI) 预测了zFEV1和zFVC的正常/高轨迹.
- 4岁时增加的体力活动和更高的zBMI预测了zFEV1的追赶,但没有发现zFVC追赶的预测因素.
结论:
- 对于FEV1和FVC,存在三个并行和一个追赶轨迹.
- 4岁时的体力活动和体重是FEV1追赶增长的预测因素.
- 在这个队列中,FVC追赶增长的预测因素仍然未被确定.
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