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The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Inflammatory Response01:28

Inflammatory Response

2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
Inflammation01:38

Inflammation

53.4K
Overview
53.4K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

11.1K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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相关实验视频

Updated: Jul 1, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

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炎症和瘤的微环境

Tao Niu1, Fenghai Zhou2

  • 1First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou 730000. 379171172@qq.com.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
|March 6, 2024
PubMed
概括

炎症通过改变瘤微环境,显著影响癌症的进展和治疗. 了解这种复杂的相互作用对于开发新型抗癌疗法至关重要.

科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学

背景情况:

  • 炎症是癌症的公认标志,影响瘤进展,恶性瘤和化疗反应.
  • 瘤微环境 (TME) 包括各种因素和信号通路,调节瘤生物学.
  • 炎症和TME之间的相互作用可以导致免疫抑制或抗瘤免疫反应.

研究的目的:

  • 审查炎症对瘤微环境的多方面的影响.
  • 阐明炎症因素和非编码RNA在瘤发育和进展中的作用.
  • 探索在TME内向炎症的治疗影响.

主要方法:

  • 文献综述侧重于TME,炎症体,细胞因子和非编码RNA的组成部分.
  • 分析控制炎症和TME之间的相互作用的信号机制.
  • 综合当前关于非编码RNAs在调节瘤-炎症动态中的作用的知识.

主要成果:

  • 炎症深刻地塑造了TME,影响了免疫抑制和抗瘤免疫力.
  • 炎症因素和非编码RNA是瘤发育,发育和对治疗的反应的关键调节者.
  • 在TME内,特定的信号通路调解癌症和炎症之间的双向通信.
关键词:
循环RNA 是一种循环RNA.这是一种炎症炎症炎症炎症.瘤是一个瘤.瘤微环境是一个微环境.

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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In Vitro Assay to Study Tumor-macrophage Interaction
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In Vitro Assay to Study Tumor-macrophage Interaction

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相关实验视频

Last Updated: Jul 1, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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In Vitro Assay to Study Tumor-macrophage Interaction
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In Vitro Assay to Study Tumor-macrophage Interaction

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结论:

  • 针对炎症和TME之间的复杂关系为癌症治疗提供了有前途的途径.
  • 对非编码RNA和炎症媒介的进一步研究可以揭示新的治疗策略.
  • 对瘤-炎症轴的全面理解对于推进癌症治疗至关重要.