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基因表达分析显示,儿童对疟疾的反应因年龄不同而有差异

Kieran Tebben1,2, Salif Yirampo3, Drissa Coulibaly3

  • 1Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.

Nature communications
|March 6, 2024
PubMed
概括

儿童的疟疾感染因寄生虫水平和年龄而异. 较高的寄生虫密度会影响免疫细胞水平,而年龄会影响免疫反应和寄生虫发育在症状的虫疟疾.

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...