Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Determination01:51

Determination

18.5K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
18.5K
Muscles for Facial Expressions01:14

Muscles for Facial Expressions

2.0K
The craniofacial muscles are a collection of approximately 20 thin skeletal muscles situated beneath the skin of the face and scalp. These muscles, primarily responsible for the vast array of human facial expressions, originate from the bones or fibrous structures of the skull and extend outwards to connect with the skin. While most skeletal muscles in the body are enveloped in thick fascia, facial muscles generally have a more delicate fascial covering, with the buccinator muscle being a...
2.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Notch Signaling Reprograms Glial Lipid Metabolism to Promote Hypoxia Resistance.

bioRxiv : the preprint server for biology·2026
Same author

Correcting spatial transcriptomics data affected by a prevalent transcript leakage problem across platforms, species, and tissues.

bioRxiv : the preprint server for biology·2026
Same author

A Coral-Inspired Dual Modal Hydrogel Sensor with Deep Learning-Assisted Decoupling of Force-Thermal Stimuli.

ACS applied materials & interfaces·2026
Same author

Associations between fentanyl exposure, gut microbiome and neurodevelopmental outcomes in preterm infants.

Pediatric research·2026
Same author

Multimodal PCSC Sensors for Real-Time Temperature and Force Detection Using LRTNet.

Sensors (Basel, Switzerland)·2026
Same author

Scaling human liver microphysiological systems: implementing a higher-throughput liver acinus microphysiological system platform.

Experimental biology and medicine (Maywood, N.J.)·2026

相关实验视频

Updated: Jul 1, 2025

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.1K

人类面发育中的动态增强器景观.

Sudha Sunil Rajderkar1, Kitt Paraiso1, Maria Luisa Amaral2

  • 1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, 94720, USA.

Nature communications
|March 6, 2024
PubMed
概括

了解人类面部发育和出生缺陷是一项挑战. 这项研究绘制了面增强剂的地图,揭示了它们的活动模式,以帮助遗传研究.

更多相关视频

Creating Avian Forebrain Chimeras to Assess Facial Development
04:10

Creating Avian Forebrain Chimeras to Assess Facial Development

Published on: February 18, 2021

1.1K
Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
07:26

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Published on: April 1, 2022

1.9K

相关实验视频

Last Updated: Jul 1, 2025

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.1K
Creating Avian Forebrain Chimeras to Assess Facial Development
04:10

Creating Avian Forebrain Chimeras to Assess Facial Development

Published on: February 18, 2021

1.1K
Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
07:26

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Published on: April 1, 2022

1.9K

科学领域:

  • 遗传学和发育生物学
  • 发展的基因组调节

背景情况:

  • 人类面部变异和头骨面部出生缺陷的遗传基础尚未得到充分理解.
  • 转录增强剂在面发育过程中对于精确的基因表达至关重要,但它们的基因组位置和细胞特异性活动在很大程度上未被绘制出来.

研究的目的:

  • 创建一个全面地图的监管景观管理人类面发育.
  • 在单细胞分辨率下识别和描述面增强剂及其活动模式.

主要方法:

  • 集成的组织蛋白修饰,染色质可访问性和人类面发育的基因表达概况.
  • 采用对正在发育的小鼠脸部单细胞分析来推断增强剂的活性.
  • 为成千上万的人类面增强器生成时间活动档案.

主要成果:

  • 定义了面部发育在组织和单细胞分辨率的监管格局.
  • 提供了14,000个人类发育面增强器的时间活动概况.
  • 在小鼠模型中确定了56%的人类面增强剂的保存色素可访问性,预测了它们在细胞类型和胚胎阶段的体内活性.

结论:

  • 这项研究为研究人类面发育的遗传和发育基础提供了广泛的资源.
  • 这些数据有助于在人类遗传学和疾病研究中对面增强剂进行系统的探索.