短时间服用蔓越提取物补充剂会调节人类肠道微生物群,并表现出双生效
Jacob Lessard-Lord1,2,3, Charlène Roussel1,2,4, Joseph Lupien-Meilleur1,2,5
1Institute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval University, Québec, QC, Canada.
NPJ biofilms and microbiomes
|March 6, 2024
概括
富含多和寡糖类的蔓越提取物在人类中积极调节肠道微生物群. 它增加了有益的细菌,改变了短链脂肪酸,并根据Prevotella的存在显示了个性化的效果.
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 人类健康 人类健康 人类健康
背景情况:
- 蔓越的健康益处与多有关,但临床结果因肠道微生物群相互作用而有所不同.
- 关于蔓越对肠道微生物群组成和功能的影响,人类的数据有限.
- 蔓越还含有寡糖,可能有助于其生物活性.
研究的目的:
- 为了描述蔓越提取物中的多和寡糖含量.
- 评估蔓越提取物对人类肠道微生物群组成和短链脂肪酸 (SCFA) 的影响.
- 为了探索对蔓越补充剂的反应中个体间的变异性.
主要方法:
- 在商用蔓越提取物中分析聚和寡糖含量.
- 补充28个人类受试者用蔓越提取物四天.
- 评估便微生物群的组成,血和便的SCFA,以及基于微生物群资料的分层.
主要成果:
- 蔓越提取物显示出显著的双生效,并增加了酸盐产生细菌 (例如,克洛斯特里,Anaerobutyricum).
- 补充剂改变了SCFA概况,降低了酸盐比率和增加了酸盐比率.
- 在补充后,在微生物群中含有Prevotella的个体显示了Faecalibacterium的显着增加.
结论:
- 富含多和寡糖的蔓越提取物可以在短时间内积极调节人类肠道微生物群.
- 提取物影响SCFA的产生,可能有助于蔓越的健康益处.
- 个体肠道微生物群的组成影响了对蔓越补充剂的反应,突出了个性化的效果.
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