由于气道关闭而引起的阴道反射
Michael S Schappe1, Philip A Brinn1, Narendra R Joshi1
1Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Nature
|March 6, 2024
概括
研究人员发现一种新的神经反射, 这种反射涉及专门的肺细胞 (神经皮质体) 和PIEZO2蛋白,这对维持呼吸功能至关重要.
科学领域:
- 神经科学
- 呼吸系统生理学
- 机械感应
背景情况:
- 呼吸道的完整性对于呼吸功能至关重要,
- 呼吸道阻塞和肺容量下降在呼吸系统疾病中很常见,可能危及生命.
研究的目的:
- 通过呼吸道关闭引起的迷走神经的新型神经反射.
- 识别特定的神经通道和参与检测气道关闭的细胞组件.
- 了解这种反射在维护呼吸功能中的作用.
主要方法:
- 在体内静脉成像以识别专门的感觉神经元.
- 刺激和消去性PVALB神经元和神经上皮体 (NEB).
- 在NEB中进行单细胞RNA测序和向基因淘汰 (Piezo2).
主要成果:
- 专门的神经元检测呼吸道的压缩, 而不是伸展.
- 表达PVALB的神经元和肺部NEB介导气道关闭反应.
- 刺激NEB或PVALB神经元会引起喘气; 切除它们会消除对气道关闭的反应.
- 在NEB中均表达PIEZO2,并且在NEB中消除了气道关闭反应.
- NEB与调解赫林格-布鲁尔灵气反射的结构不同.
结论:
- 一个涉及PVALB神经元和PIEZO2表达NEB的专用道检测气道关闭.
- 这种反射对于在呼吸道受阻时保持呼吸功能至关重要.
- 神经皮质体作为肺部的关键机械传感器, 类似于触觉中的默克尔细胞.
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