在患有自闭症谱系障碍的学龄前儿童中,与长时间的屏幕时间相关的脑内和网络间功能连接的改变
Yang Xue1,2, Miao-Shui Bai1,2, Han-Yu Dong1,2
1Department of Developmental and Behavioral Pediatrics, Children's Hospital of the First Hospital of Jilin University, The First Hospital of Jilin University, Jilin University, Changchun, China.
European journal of pediatrics
|March 6, 2024
概括
患有自闭症谱系障碍 (ASD) 的儿童的长时间屏幕时间 (ST) 与更严重的自闭症特征和较低的语言发展有关. 这项研究揭示了ASD儿童与高ST暴露的改变大脑网络连接.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿科 儿科 儿科
背景情况:
- 长时间的屏幕时间 (ST) 对儿童的自闭症特征和语言发展产生负面影响.
- 自闭症谱系障碍 (ASD) 中长期ST影响的潜在神经发育机制尚未完全理解.
- 神经成像提供了一个潜在的工具,以阐明ST在ASD中的作用.
研究的目的:
- 研究延长屏幕时间 (ST) 对自闭症谱系障碍 (ASD) 儿童大脑网络功能连接 (FC) 的影响.
- 探索ST持续时间和神经发育结果之间的关系,包括自闭症特征和语言发展,在患有ASD的儿童中.
主要方法:
- 空间独立组件分析 (ICA) 用于识别静止状态网络 (RSN).
- 分析了164名患有自闭症儿童的网络内部和网络间功能连接 (FC) 改变,分为低剂量 (LDE) 和高剂量 (HDE) ST暴露组.
- 评估了儿童自闭症评分表 (CARS) 的分数和听力和语言的发育系数 (DQ).
主要成果:
- 与ST暴露较低的组 (LDE组) 相比,高ST暴露 (HDE组) 的儿童显示出明显更高的CARS得分和较低的听力和语言DQ.
- HDE组在默认模式网络 (DMN),执行控制网络 (ECN) 和注意网络 (ATN) 中显示出 FC 降低,在突出网络 (SAN) 中显示出 FC 增加.
- 网络间分析显示,在HDE组中,视觉,基底,感觉运动,听觉和DMN网络之间发生了改变的FC. 中间椎 (MTG) 的改变FC与CARS分数负相关.
结论:
- 患有自闭症儿童的长期ST与更严重的自闭症特征和语言发育障碍有关.
- 改变网络内部和网络间的功能连接性代表了长期ST对ASD神经发育的影响的潜在神经成像生物标志物.
- 这些发现强调了管理ASD儿童屏幕时间的重要性,以支持健康的神经发育.
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