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Updated: Jul 1, 2025

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
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Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta

Published on: December 5, 2019

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由MAGEA4调节RAD18的结构基础及其对MAGE家族蛋白质对RING泛素酶结合的影响

Simonne Griffith-Jones1, Lucía Álvarez2, Urbi Mukhopadhyay1

  • 1European Molecular Biology Laboratory, 71 Avenue des Martyrs, 38042, Grenoble, France.

The EMBO journal
|March 6, 2024
PubMed
概括

癌症丸抗原MAGEA4与RAD18相互作用,抑制其自我ubiquitination并影响DNA修复. 这种通过NMR和AlphaFold2阐明的相互作用揭示了癌症治疗的潜在目标.

关键词:
马盖亚4是什么意思在RAD18中使用RAD18.在RAD6中,使用RAD6.转变损伤DNA合成乌比奎丁是一种存在的药物.

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