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与爆炸有关的轻度创伤性脑损伤和执行功能之间的关系是由白质完整性调节的

Molly C O'Brien^1,2, Seth G Disner^3,4, Nicholas D Davenport^3,4

¹Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA. mollyobrien314@gmail.com.

Brain imaging and behavior

|March 6, 2024

概括

白质完整性,特别是海马环膜,影响了与爆炸有关的轻度创伤性脑损伤 (BR mTBI) 的退伍军人的认知结果. 这条通道的完整性较低与BR mTBI史患者的执行功能较差有关.

科学领域:

神经科学是一个神经科学.
创伤性脑损伤研究研究
退伍军人健康退伍军人的健康

背景情况:

与爆炸有关的轻度创伤性脑损伤 (BR mTBI) 是战斗退伍军人日益关注的问题.
经BR mTBI后的异质结果需要了解神经系统的基础.
识别神经学差异可以帮助预测认知缺陷.

研究的目的:

调查通过扩散张力成像 (DTI) 测量的白质完整性是否影响BR mTBI史和执行控制之间的关联.
探索特定白质区域对BR mTBI退伍军人的认知表现的调节作用.

主要方法:

来自明尼阿波利斯VA医疗中心的151名退伍军人接受了临床/TBI评估,神经心理测试和DTI扫描.
分析了六个预先选择的白质通道的微分异质性 (FA) (环膜,海马环膜,皮质脊髓通道,下面的前后带,上长 longitudinal fasciculus,未切割).
多重线性回归模拟了Trail-Making Test B (TMT-B) 绩效的预测因素,包括BR mTBI历史和白质FA.

主要成果:

海马环膜的微分异型性 (FA) 显著缓解了BR mTBI史和较差的TMT-B表现之间的关系 (p < 0.008).
下海马带环FA与更糟糕的TMT-B结果有关,特别是在报告BR mTBI的个体中.
对于其他路径或除了BR mTBI历史之外的其他预测因素,没有发现显著的适度.

结论:

白质完整性,特别是在海马环膜,在BR mTBI后的执行功能中起着至关重要的作用.
这项通道层次的调查突出了与爆炸有关的和与爆炸无关的大脑损伤之间的潜在神经学区别.
研究结果表明,基于DTI对白质完整性的评估可能有助于理解和预测BR mTBI退伍军人的认知结果.

关键词:

强大的爆炸.在Cingulum中使用.执行职能执行职能执行职能退伍军人是一名退伍军人.mTBI mTBI 的意思是什么

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