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在老年住院患者中,Clostridioides difficile感染的复发和死亡率

Francesca Remelli¹, Irene Mattioli², Benedetta Govoni³

¹Department of Medical Science, University of Ferrara, Via Aldo Moro, 8, 44124, Ferrara, Italy.

European geriatric medicine

|March 6, 2024

概括

在老年人中复发的Clostridioides difficile感染显著增加了死亡风险. 范科米辛治疗与复发率较低的梅트로尼达相比,与较低的复发率有关,这表明潜在的治疗优势.

科学领域:

老年医学老年医学
传染性疾病传染性疾病
流行病学流行病学

背景情况:

艰难菌感染 (CDI) 在老年,脆弱的人群中非常普遍,导致经常出现复发和死亡等不良结果.
老年人CDI复发的特定临床风险因素仍然不完全理解.

研究的目的:

调查老年人中Clostridioides difficile复发和6个月死亡率之间的联系.
确定导致Clostridioides difficile在出院后复发的风险因素.

主要方法:

从2018年1月到2020年12月,对386名成年患者进行了回顾性研究,这些患者首次患有Clostridioides difficile感染 (CDI).
收集的数据包括社会人口统计,临床和实验室信息.
主要结局:死亡率;次要结局:CDI在6个月内复发.

主要成果:

患者的平均年龄为77.8岁,其中61.7%为女性.
12%的人经历了CDI复发,32.1%的人在6个月内死亡.
CDI复发与死亡风险增加两倍相关 (HR:2.45). 范科米辛治疗显示复发风险低于甲尼达 (p < 0.001).

结论:

复发的Clostridioides difficile是增加死亡率的重要预测因素,可能表明潜在的脆弱性.
在传染性发作期间的万科米辛治疗与较低的CDI复发率相比,与metronidazole相关.

关键词:

克洛斯特里迪奥伊德困难感染.年长的老年人.死亡率死亡率死亡率复发情况复发情况

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