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老年患者的皮肤黑色素瘤
Alessandra Buja1, Massimo Rugge2,3, Chiara Trevisiol4
1Hygiene and Public Health Unit, Laboratory of Health Care Services and Health Promotion Evaluation, Department of Cardiologic, Vascular and Thoracic Sciences, and Public Health, University of Padua, Via Loredan, 18, 35131, Padua, Italy. alessandra.buja@unipd.it.
BMC geriatrics
|March 6, 2024
概括
老年患者的皮肤恶性黑色素瘤 (CMM) 呈现不同,发病率较高,并且处于晚期. 这凸显了为老龄化人口量身定制的诊断和治疗策略的需要.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 老年病的医生 老年病的医生
背景情况:
- 工业化国家人口老龄化的增加.
- 在老年人中增加皮肤恶性黑色素瘤 (CMM) 的发病率.
- 专注于老年CMM患者的临床病理学概况和诊断治疗性能.
研究的目的:
- 调查老年人中CMM的临床病理特征.
- 评估老年CMM患者的诊断-治疗性能指标.
- 识别CMM呈现和管理中的特定年龄模式.
主要方法:
- 从2017年开始,对1368例发生的CMM病例进行了以人口为基础的回顾性队列研究.
- 定义的年龄组:老年人 (≥80),老年人 (65-79) 和成年人 (<65).
- 统计分析包括克莱默-V,有序后勤回归和克洛珀-皮尔森精确方法.
主要成果:
- 80岁以上的CMM患者表现出明显的地形,较高的发病率 (43.3%与12.7%相比),与年轻患者相比,Breslow指数增加.
- 老年患者呈现出更先进的pTNM阶段和较低的瘤透淋巴细胞的患病率.
- 阳性哨兵淋巴结的老年患者较少接受进一步的外科手术.
结论:
- 年长的CMM患者表现出独特的临床病理学表现.
- 这些发现强调了对老年人进行优化二次预防策略的需要.
- 完善诊断治疗程序对于改善老年CMM患者的治疗结果至关重要.
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