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针对晚期状非小细胞肺癌的免疫疗法的成本效益:系统性审查

Minyu Cheng¹, Yanfei Shao², Li Li¹

¹Department of Pharmacy, Zhejiang Hospital, 310013, Hangzhou, China.

|March 6, 2024

概括

针对肺状细胞癌 (LSCC) 的免疫检查点阻断 (ICB) 疗法具有不同的成本效益. 布罗利祖马布与化疗是目前最具成本效益的,但当地的中国疗法为中国付款人提供了更好的价值.

科学领域:

在瘤学瘤学.
药物经济学药物经济学
医疗保健服务研究医疗服务研究

背景情况:

肺状细胞癌 (LSCC) 治疗涉及免疫检查点阻断 (ICB) 疗法,具有不同的经济影响.
需要进行系统审查,以评估ICB疗法的成本效益,特别是针对LSCC.
本研究旨在全面审查和评估现有的关于在LSCC治疗中ICBs的药物经济研究.

研究的目的:

系统地审查和评估免疫检查点阻断 (ICB) 治疗肺状细胞癌 (LSCC) 的药物经济数据.
根据现有证据,确定LSCC最具成本效益的ICB治疗策略.

主要方法:

在PubMed,EMBASE,Cochrane图书馆和科学网络中进行系统的电子搜索,直到2023年6月.
纳入标准集中在人口,干预,比较器,结果和药物经济研究的研究设计上.
使用德拉蒙德检查表来评估偏见和研究设计的纳入研究的质量评估.

主要成果:

审查了15篇关于对LSCCICB治疗的经济评估的文章.
尼沃卢马布单一治疗显示出比单独化疗更大的成本效益.
布罗利祖马布加化学疗法目前是最具成本效益的组合,当地开发的sintilimab或toripalimab加化学疗法对中国纳税人来说更具成本效益.

结论:

研究设计和结果的异质性需要谨慎地解释研究结果,只支持定性综合.
未来的研究应该优先研究当地开发的ICB疗法对中国市场的成本效益.
专注于国内治疗可能会为中国患有LSCC的患者提供比进口药物更好的价值.

关键词:

卡姆雷利兹马巴姆 (Camrelizumab) 是一个经济效益性经济效益性免疫治疗是一种免疫疗法.尼沃卢马布的使用情况非小细胞肺癌是非小细胞肺癌.这就是Pembrolizumab.这就是Sintilimab.建议使用金钱.在Toripalimab上使用.

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