相关实验视频

Updated: Jul 1, 2025

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

鉴定ANKRD13D作为细胞癌的潜在标

Wenqian Zhou¹, Yonghe Huang², Jing Liu¹

¹Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

The International journal of biological markers

|March 7, 2024

概括

安基林重复域13D (ANKRD13D) 是细胞癌中一个关键的免疫调节剂. 通过免疫检查点阻塞准ANKRD13D可能会增强这种癌症的免疫治疗策略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物信息学是一种生物信息学.

背景情况:

研究了林重复域 (ANKRD) 家族基因表达和细胞癌 (RCC) 患者结局之间的联系.
在ANKRD家族中确定了RCC.的潜在预后标志物.

研究的目的:

为了确定与RCC预后相关的特定ANKRD家族成员.
阐明ANKRD13D在RCC免疫中的作用及其作为治疗点的潜力.

主要方法:

使用多个公共数据库 (GEPIA2, GEO2R, UALCAN, GDC, OncoLnc, TIMER, PanglaoDB, CancerSEA, Tabula Muris) 来进行数据分析.
进行单细胞表达分析和逆转录定量聚合酶链反应 (RT-qPCR) 验证结果.
使用AlphaFold用于ANKRD13D的结构预测.

主要成果:

在RCC样本中鉴定出12个过度表达的ANKRD家族成员.
证实ANKRD13D是RCC特异性标,主要表达在免疫细胞,特别是调节性T细胞 (Tregs) 中.
ANKRD13D表达与Treg透和免疫检查点标记物 (PDCD1,CTLA4,LAG3,TNFSF14,ISG20) 有积极的相关性.

结论:

ANKRD13D在RCC.的瘤微环境中起到关键的免疫调节作用.
通过免疫检查点封锁向ANKRD13D是一个有希望的治疗策略,用于增强RCC免疫疗法.

关键词:

在 ANKRD13D 中,在UIMIM中,UIMIM是UIMIM.免疫检查点是一个检查点.细胞癌是细胞癌.商业贸易商业贸易是什么?

更多相关视频

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Published on: April 29, 2014

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

相关概念视频

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...