癌症诊断后身体功能低下与绝经后妇女的死亡风险更高有关
Paola Gonzalo-Encabo1,2,3, Alexi Vasbinder4, Jennifer W Bea5
1Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Journal of the National Cancer Institute
|March 7, 2024
概括
绝经后妇女癌症诊断后身体功能下降与死亡风险增加有关. 保持身体功能可以显著降低死于任何原因或癌症的几率.
科学领域:
- 在瘤学瘤学.
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 癌症及其治疗方法加速了绝经后妇女的身体功能障碍.
- 这种功能障碍超过了与年龄相关的衰退.
- 对死亡风险的影响需要调查.
研究的目的:
- 研究癌症诊断后身体功能下降与死亡率之间的关联.
- 为了确定是否减少的身体功能预测所有原因和癌症特定的死亡率.
主要方法:
- 对8068名患有癌症的绝经后妇女进行前性队列研究.
- 在诊断后1年内使用SF-36物理功能子表进行评估的身体功能.
- 通过医疗记录,中央裁决和国家死亡指数联系收集到的死亡数据,直到2022年2月.
主要成果:
- 诊断后身体功能得分的10%改善与所有原因和癌症特定死亡率的12%降低有关.
- 在身体功能类别和死亡率之间观察到显著的剂量反应关系.
- 身体功能四分之一最高的女性的平均存活时间为18.4年,而最低四分之一的女性的平均存活时间为9.1年.
结论:
- 癌症后诊断的低身体功能是绝经后妇女死亡的重要风险因素.
- 改善或维持身体功能的干预措施可能会改善生存结果.
相关概念视频
Menopause
158
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
158
Cancer Survival Analysis
345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
Disorders of the Female Reproductive System
358
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
358
Lifestyle Factors and Health
47
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
47


