无脊椎动物免疫记忆的可塑性 无脊椎动物免疫记忆的可塑性
Humberto Lanz-Mendoza1, Dumas Gálvez2,3,4, Jorge Contreras-Garduño5,6
1Centro de Investigaciones sobre Enfermedades Infecciosas, INSP, 62100 Cuernavaca, Morelos, Mexico.
无脊椎动物可能具有免疫记忆,在暴露于病原体后提供特定的保护. 然而,证据是混合的,影响这种无脊椎动物免疫反应的因素需要进一步调查.
科学领域:
- 免疫学 免疫学 免疫学
- 无脊椎动物生物学 脊椎动物生物学
背景情况:
- 由于无脊椎动物缺乏适应性免疫成分,如抗体,B细胞和T细胞,免疫记忆的存在一直受到争论.
- 虽然一些研究表明无脊椎动物具有特定菌株的免疫记忆,但其他研究则提供相互矛盾或部分支持.
研究的目的:
- 审查无脊椎动物免疫记忆的证据.
- 探索影响无脊椎动物免疫反应变化的因素.
- 为了突出表型可塑性在无脊椎动物免疫记忆中的不足研究的作用.
主要方法:
- 在过去二十年中,对无脊椎动物免疫记忆的研究进行文献评论.
- 对调查无脊椎动物菌株特异性免疫力的研究进行分析.
- 检查影响免疫反应变化的因素.
主要成果:
- 有证据支持各种无脊椎动物类 (Ctenophora,Cnidaria,Nematoda,Mollusca,Arthropoda) 的免疫记忆.
- 无脊椎动物的免疫记忆可以是菌株特异性的,但它的存在和特征有很大差异.
- 两相免疫反应,典型的脊椎动物适应性免疫,是不一致的无脊椎动物.
结论:
- 无脊椎动物的免疫记忆是合理的,但复杂的,受到包括寄生虫在内的环境和生物因素的影响.
- 现型可塑性在无脊椎动物免疫记忆中的作用需要进行系统的调查.
- 需要进一步的研究,以充分描述无脊椎动物在不同环境中的免疫反应.
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