产前压力是如何从母亲传播给胎儿的?
Ying Sze1, Paula J Brunton1,2
1Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK.
The Journal of experimental biology
|March 7, 2024
概括
产前压力会导致长期的神经内分泌和行为变化后代,特别是男性. 本综述探讨了包括神经类固醇信号在内的机制,并质疑母体葡萄皮质激素在这种编程中的直接作用.
科学领域:
- 神经内分泌学神经内分泌学
- 发展心理学 发展心理学
- 行为神经科学 行为神经科学
背景情况:
- 怀孕期间母亲的压力会导致长期的神经内分泌和行为改变后代.
- 产前应激暴露与性别特定的不适应编程有关,包括男性的焦虑增加.
- 下垂体-垂体-上腺 (HPA) 轴对压力的反应往往在暴露于产前压力的后代中失调.
结论:
- 其他途径,可能涉及间接的葡萄皮质激素作用或胎盘适应,可能会调解母亲压力对后代的影响.
- 了解这些机制对于开发针对产前压力诱导的发育障碍的干预措施至关重要.
- 需要进一步的研究来阐明精确的信号通路,从母亲的压力到胎儿的编程.
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