血清纤维细胞生长因子23度和患有腹膜透析的患者的死亡风险
Zhong Zhong1,2,3, Shaozhen Feng1,2,3, Dongying Fu1,2
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
概括
纤维细胞生长因子23 (FGF23) 的高水平与腹膜透析 (PD) 患者的感染相关死亡率增加相关. 这一发现突出了FGF23作为PD患者感染并发症的潜在风险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 纤维细胞生长因子23 (FGF23) 是一种调节酸盐水平的关键激素.
- 在慢性病的早期观察到FGF23的升高.
- 腹透析 (PD) 患者结局中FGF23的作用需要进一步研究.
研究的目的:
- 为了检查血清FGF23水平与腹腔透析 (PD) 患者的死亡率之间的关联.
- 为了确定与FGF23度相关的特定死亡风险,在发生PD患者中.
主要方法:
- 一项为期15年的前性队列研究使用ELISA分析了737例PD患者的血清FGF23水平.
- 使用了卡普兰-梅尔生存分析和考克斯比例危险模型.
- 对潜在混因素进行调整的统计分析,以评估FGF23对死亡率的影响.
主要成果:
- 基线FGF23度的中位数为683.2 pg/mL.
- 在随访期间,23.2%的患者死亡,与感染相关的死亡是显著的.
- 多变量分析显示,最高的FGF23三位数与感染相关死亡风险增加2.66倍相关 (p=0.022).
结论:
- 血清FGF23度升高是发生PD患者感染相关死亡率增加的重要预测因素.
- 在这个人群中,FGF23可以作为评估感染风险的有价值生物标志物.
- 需要进一步的研究来探索针对PD患者FGF23的治疗策略.
相关概念视频
01:27Dialysis
309
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
309
01:17Factors Affecting Renal Clearance: Renal Impairment
91
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
91
01:11Renal Failure: Dose Adjustments
88
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
88