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佩里拉果的作用瓦尔. 在Busulfan诱导的精子生成功能障碍中的Acuta鼠标模型

Hyung Jong Nam^1,2, Min Jung Park^3,4, Bo Sun Joo^3,4,5

¹Department of Urology, Pusan National University School of Medicine, Busan, Korea.

The world journal of men's health

|March 7, 2024

概括

佩里拉水果种类 (Perilla frutescens var.) 是一种植物. acuta (PFA) 能防止布苏尔诱导的丸损伤和氧化应激. PFA改善精子质量和激素水平,表明其在减轻化疗副作用方面的潜在用途.

科学领域:

生殖生物学生殖生物学
毒理学毒理学毒理学
药理学药理学是指药理学的学科.

背景情况:

佩里拉水果种类 (Perilla frutescens var.) 是一种植物. acuta (PFA) 是一种传统的东亚药物,具有已知的抗氧化和抗炎性质.
布苏尔是一种化疗剂,可以诱导丸功能障碍和氧化应激.

研究的目的:

在小鼠模型中研究PFA对busulfan诱导的丸损伤的保护作用.
评估PFA的抗氧化活性,以减轻busulfan诱导的氧化应激,组织学损伤和精子质量下降.

主要方法:

雄性C57BL/6小鼠接受了布苏尔方治疗,以诱导丸功能障碍.
小鼠在布苏尔给药后的35天内口服了不同度的PFA (100和200毫克/公斤).
评估的参数包括丸体重,丸组织病理学,精子质量,血清激素水平和氧化应激标志物.

主要成果:

布苏尔方治疗显著降低了丸体重,精子质量和荷尔蒙水平,同时增加了氧化应激.
PFA治疗剂量取决于丸体重,精子数,运动性和水平的增加.
酸调节了抗氧化酶表达 (Sod1,Gpx1),减少了酸 (MDA),增加了SOD和GPx活动,表明氧化应激减少.

结论:

通过减轻氧化应激,PFA显示出显著的保护作用,防止busulfan诱导的丸损伤.
PFA可能是一种有益的辅助疗法,以减少与busulfan化疗相关的丸毒性.

关键词:

抗氧化剂抗氧化剂是一种抗氧化剂.布苏尔夫人布苏尔夫人布苏尔夫人药物治疗是药物治疗.佩里拉果 (Perilla frutescensens) 是一种鲜花的植物.精子发生是精子生成.

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