一项试点研究,探索长效注射抗精神病药对攻击性的影响
Tiffany M Hopkins1, O Greg Deardorff2, Yifei Liu3
1Hopkins, PharmD, BCPP, Clinical Pharmacy Specialist, South Texas Veterans Health Care System, San Antonio, TX.
Psychopharmacology bulletin
|March 7, 2024
概括
切换到长效注射 (LAI) 抗精神病药物并没有显著改变侵略性或自我伤害. 然而,LAI抗精神病药似乎减少了对限制和隔离的需要.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗精神病药物是管理严重精神疾病的核心.
- 长效注射 (LAI) 抗精神病药物为口服配方提供了替代的注射途径.
- 了解从口服转换为LAI抗精神病药物的影响对于患者护理至关重要.
研究的目的:
- 评估从口服抗精神病药物过渡到LAI抗精神病药物的效果.
- 评估侵略,干预,自我伤害,隔离/克制,拒绝服用药物和使用PRN抗精神病药物的变化.
主要方法:
- 在国家法医精神病医疗机构的回顾性病理表审查.
- 纳入标准:至少服用口服抗精神病药6个月,然后服用LAI抗精神病药6个月.
- 数据收集了超过80个月的时间.
主要成果:
- 这项研究包括18名患者.
- 攻击事件显示出不同的结果:两个增加,三个减少,两个不变.
- 在切换到LAI抗精神病药物后,干预减少了30.6%.
- 限制/隔离使用减少,而拒绝药物和使用PRN抗精神病药物显示出各种变化.
结论:
- 切换到LAI抗精神病药物并没有显著增加或减少侵略性或自我伤害行为.
- 抗精神病药物似乎减少了对限制和隔离的要求.
- 可能需要进一步的研究来充分阐明对所有测量结果的影响.
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