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使用Fibra-Cel®宏运载体提高了rVSV-SARS-CoV-2疫苗的生产产量

Noam Cohen1, Irit Simon1, Ophir Hazan1

  • 1Department of Biotechnology, Israel Institute for Biological Research, Ness-Ziona, Israel.

Frontiers in bioengineering and biotechnology
|March 7, 2024
PubMed
概括

在生物反应器中使用宏载体的新型生物工艺显著增强了SARS-CoV-2疫苗 (rVSV-ΔG-spike) 的生产. 这种可扩展的方法实现了高病毒标位,提高了疫苗制造能力.

关键词:
这是VSVVVVVV.生物过程生物过程.固定床生物反应器 固定床生物反应器遗传稳定性 遗传稳定性在生产生产生产生产生产生产.病毒疫苗 疫苗 病毒疫苗

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Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...