免疫治疗结合疗法对子宫内膜癌的成本效益
David J Benjamin1, William V Padula2,3, Robert C Hsu4
1Hoag Family Cancer Institute, Newport Beach, CA, USA.
Gynecologic oncology reports
|March 7, 2024
概括
针对妇科癌症的新向疗法和免疫疗法正在出现,但成本效益分析显示,对于晚期子宫内膜癌的组合疗法在标准支付意愿值下是不具有成本效益的.
科学领域:
- 妇科瘤学 妇科瘤学
- 卫生经济学 卫生经济学
- 药物经济学 药物经济学
背景情况:
- 最近几年 (2019-2023) 已经看到FDA批准了针对宫,卵巢和子宫内膜癌复发的新型向疗法和免疫疗法.
- 金融毒性是癌症护理中日益关注的问题.
- 这项研究侧重于最近FDA批准的妇科瘤学,特别是子宫内膜癌.
研究的目的:
- 从2019年到2023年,审查FDA在妇科瘤学方面的批准.
- 对复发性或晚期子宫内膜癌的批准组合疗法进行成本效益分析.
- 在医疗保健系统的背景下,评估新的癌症治疗方法的经济价值.
主要方法:
- 在2019年至2023年期间,审查了FDA在妇科瘤学方面的批准.
- 确定了针对子宫内膜癌批准的特定组合疗法.
- 进行了成本效益分析,比较pembrolizumab加lenvatinib和 dostarlimab加化疗与安慰剂,使用等价值的生命年增长 (evLYG).
主要成果:
- 美国食品和药物管理局的批准包括pembrolizumab加lenvatinib,pembrolizumab单疗法,tisotumab vedotin和dalarlimab (单独或与化疗).
- 成本有效性分析表明,无论是pembrolizumab加lenvatinib还是 dostarlimab加化疗都不是成本有效的,每年每年支付10万美元的支付意愿.
- 这些新型疗法的高成本被医疗保健系统吸收,这可能会影响整体医疗保健支出.
结论:
- 对于复发性子宫内膜癌的新疗法虽然有前途,但却面临着巨大的成本挑战.
- 分析的当前组合方案在评估的经济框架内没有被发现具有成本效益.
- 这些治疗对医疗保健系统的经济负担需要进一步评估患者的价值和可访问性.
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