在患有壮症的妇女中,仍然存在高死亡风险
Simona Găloiu1,2, Iustin-Daniel Toma1, Denisa Isabella Tănasie1
1Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Frontiers in endocrinology
|March 7, 2024
概括
壮症患者的死亡率有所降低,特别是在新的治疗方法下. 然而,患有巨症的女性仍然面临更高的死亡率,这凸显了早期诊断和干预的必要性.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 巨症是一种罕见的内分泌疾病,由生长激素 (GH) 过量引起,与死亡率增加有关.
- 近几十年来,壮症患者的死亡率有所改善.
- 了解壮病死亡率的时间趋势和性别差异对于优化患者护理至关重要.
研究的目的:
- 确定死亡率,并确定与壮病患者死亡率相关的因素.
- 为了比较国家治疗方案实施前后的死亡率.
- 调查壮病死亡率的潜在性别相关差异.
主要方法:
- 对399名壮病患者 (2001-2022) 的回顾性观察研究.
- 收集了准临床数据,包括GH,IGF-I水平和瘤直径.
- 计算标准化死亡率 (SMR) 并使用考克斯回归来进行死亡因子分析.
主要成果:
- 总体SMR为1.18,在2008年后诊断的患者 (SMR=1.09) 和正常IGF-I治疗后患者 (SMR=0.71) 中,SMR率较低.
- 独立的死亡因素包括最后的IGF-I/GH水平,缺乏手术,淋巴腺素缺乏和年龄.
- 与男性 (0.99) 相比,女性的SMR (1.63) 较高,特别是那些在2008年之前被诊断出来的人.
结论:
- 最近被诊断为壮症患者的死亡率较低,这归因于先进的治疗方法和外科手术.
- 患有壮症的女性因晚期诊断和代谢并发症而继续经历更高的死亡率.
- 在妇女中早期诊断壮症对于减轻死亡风险至关重要.
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