相关实验视频
Updated: Jul 1, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.6K
对莱沃西软凝配方的剂量-TSH反应效应的分析
Pierpaolo Trimboli1,2, Tommaso Piticchio1,3, Zeno Dadda2
1Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Frontiers in endocrinology
|March 7, 2024
概括
新的柔软凝levothyroxine (LT4-C) 可能允许较低的初始剂量为心脏病患者. 这项研究确定了每天每人体重的LT4-C需求,以达到最佳的甲状腺激素水平.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 甲状腺学 甲状腺学
背景情况:
- 利沃甲状腺素 (LT4) 是对甲状腺功能低下症的标准治疗方法.
- 与传统药片相比,LT4 (LT4-C) 的软凝囊提供了最佳的性能.
- 目前的指导方针建议根据片剂制剂的疗效来推LT4的剂量.
研究的目的:
- 为了确定每日需要的LT4-C,按体重正常化.
- 为优化患者的LT4-C剂量提供数据.
主要方法:
- 在全甲状腺切除和放射性治疗后接受LT4-C的选定患者.
- 排除具有干扰因子或特异性TSH抑制指示的患者.
- 在研究期间保持稳定的LT4-C剂量.
主要成果:
- 30名患者 (平均年龄50岁,平均体重71公斤) 接受的中位数LT4-C剂量为1.71μg/kg/天.
- LT4-C剂量与自由T4相关 (p=0.03),但没有TSH或自由T3.
- 90%的患者达到TSH<1.0mIU/L. 90%的患者达到TSH<1.0mIU/L. 1.53μg/kg/day的剂量是达到TSH<1.0mIU/L (70%的灵敏度,100%的特异性) 的最准确的切断值.
结论:
- 胆病患者可能最初接受较低的LT4-C剂量治疗,而不是以前推的.
- 需要进一步的前性研究来证实这些发现,并完善剂量建议.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
Dose-Response Relationship: Overview
3.1K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
3.1K
Dose-Response Relationship: Potency and Efficacy
4.4K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
4.4K
Functions of Thyroid Hormones
2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K
Dosage Regimen: Fixed Dose
1.9K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
1.9K
Factors Affecting Drug Response: Overview
2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K

