相关实验视频
Updated: Jul 1, 2025

05:19
Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
10.1K
肠道微生物群与胃食道逆流性疾病风险之间的因果关系:遗传相关性和双向门德尔随机化研究
Kui Wang1,2, Suijian Wang3, Yuhua Chen4
1Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Frontiers in immunology
|March 7, 2024
概括
这项研究使用遗传数据将肠道微生物群的变化与胃食道逆流症 (GERD) 风险联系起来. 某些肠道细菌可能会防止GERD,而其他细菌则会增加风险,这表明微生态疗法的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 遗传学 是一个遗传学.
背景情况:
- 观察性研究表明,肠道微生物群和GERD之间存在联系.
- 由于混杂变量,因果关系尚不清楚.
研究的目的:
- 使用孟德尔随机化 (MR) 调查肠道微生物群和GERD之间的遗传联系.
- 为了识别与GERD风险或保护相关的特定肠道细菌.
- 探索基于肠道微生物群的潜在治疗方法.
主要方法:
- 使用了大规模的全基因组关联研究 (GWAS) 数据集来获取微生物组数据 (MiBioGen联盟).
- 从事总结级GERD GWAS数据从一个大型的欧洲队列.
- 应用逆方差加权 (IVW) 方法作为主要分析,得到灵敏度分析和反向因果关系评估的支持.
主要成果:
- 对 *Clostridiales家族Vadin BB60组*, *Lachnospiraceae UCG004* 属, *Methanobrevibacter* 属和 *Phylum Actinobacteria* 针对 GERD 的保护性关联已确定.
- 发现GERD风险增加与*Mollicutes类*,*Anaerostipes属*和*Phylum Tenericutes*有关.
- 反向因果关系分析表明,GERD在13个肠道微生物群类中导致失生症.
结论:
- 这种MR分析提供了第一个将肠道微生物群变化与GERD风险联系起来的遗传证据.
- 这些发现支持肠道微生态疗法在治疗GERD方面的潜力.
- 建立了进一步研究肠道微生物群在GERD病因学中的作用的基础.
相关概念视频
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
316
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
316
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
Gastroesophageal Reflux Disease II: Clinical Features and Management
80
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
80
Anatomy of the Intestines
71.9K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.9K
Irritable Bowel Syndrome I: Introduction
273
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
273
What is Monogastric Digestion?
71.2K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.2K

